Endocrine Abstracts

Background: Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary autosomal dominant tumor syndrome caused by inactivating mutations of the tumor suppressor gene MEN1 which encodes the protein menin. It is characterized by the occurrence of tumors involving two or more endocrine glands, primarily parathyroid, entero-pancreatic, and anterior pituitary, as well as non-endocrine neoplasms. Glucagonomas occur in fewer than 3% of patients with MEN1, causing hyper...

Aim: To evaluate: 1) clinical and epidemiological characteristics of outpatients transitioned from Pediatrics Endocrine (PED) to Adult Endocrine Department (AED) in a tertiary Centre; 2) transition process characteristics, and predictive factors of drop-out.Patients and methods: Demographic, clinical, and transition features of 170 consecutive patients with paediatric onset of chronic endocrine or metabolic disease (excluded type 1 diabetes) who transiti...

Purpose: Obesity is a chronic disease with a high risk of cardiovascular and metabolic comorbidities, hence a decrease > 5-10% of the initial body weight (BW) is essential to achieve improvement of cardiometabolic dysfunction. Bariatric surgery currently represents a valid therapeutic option in this clinical setting, especially in patients unresponsive to a dietary-nutritional approach. Obesity instigates adaptive hormone changes, yet the role of baseline hormone setting o...

Here we report a case of an adult patient (44y/o) followed for type-2 diabetes since he was 15 years, hypercholesterolemia treated with PCSK9 inhibitors and hypertension. At physical examination he presented: progeroid features, prominent forehead, hypertelorism, short palpebral fissures, broad nasal bridge, baldness, and hypotricosis. He was also affected by hearing loss with a jarring voice and lost teeth in early age. He showed developmental delay and ID, mild atrial septal...

Background: Data on the relationship between type 2 diabetes (T2D) and cancer consistently suggests the involvement of metabolic mechanisms such as inflammation, obesity, and glucose alteration. These mechanisms, including the activation of factors like IGF-1 or m-TOR, may influence the development of cancer.Aim: Our study had two main objectives. Firstly, we aimed to investigate the relationship between specific identifiable factors associated with T2D ...

Background: The incidence of type 2 Diabetes Mellitus (T2D) is increasing worldwide. Prevention is possible by changing lifestyle but it’s not effective alone in real life, due to poor compliance over time. New strategies are necessary, mostly for high-risk individuals. Therapeutic microbiology is a further proposed target, and butyrate-producing bacteria can improve metabolic parameters in obese patients. Our study aims to evaluate the effect of Intestinimonas butyri...